Truck-driver Brewster takes over his missing brother's delivery of a load of coffins to a funeral home. He picks up hitchhiking gay couple Cary and Vogel whose relationship is in trouble to help him stay awake but when his GPS leads them into a deserted junkyard, his truck breaks down, stranding them. NIght falls, and the coffins reveal blood-thirty vampires. Now the mismatched trio must barricade themselves in the cab of the truck and try to survive until dawn...

On a snowy winter night in 1964, Dr. David Henry rushes his pregnant wife Norah to the hospital, where, with help from her husband and nurse Caroline Gill, she delivers their son Paul. However, Dr. Henry discovers that his wife was carrying twins, and helps her deliver the second child, a baby girl named Phoebe. Shortly after Phoebe's birth, he finds that she has Down Syndrome, and hands her over to Nurse Caroline, explaining that the death of his ill sister nearly destroyed their mother and he doesn't want Norah to go through that. Instead, he instructs Caroline to take Phoebe to a nearby institution for the mentally ill, figuring the child won't live much longer, and tells Norah that Phoebe was a stillborn. However, after visiting the institution and seeing the state of the other patients, Caroline takes the baby home with her, stopping along the way to buy formula and diapers...

While driving to Las Vegas for the bachelor party of her sister Melissa and her fiancé Bobby, Kayla stops the car in the gas station to meet her date, Nik, a guy she met on the internet. Nik convinces her to take a secondary road under the protest of Bobby but the car breaks down. They find a house in the middle of nowhere and decide to take the car parked in the house's garage to the next city, and return with a rented car to pay for the damages provoked by Nik; Melissa leaves her cell number. However, they discover that the owner of the place is the sadistic truck driver Rusty Nail and they have to pay a high price for what they did.

It's the fall of 1969 and winds of a change are blowing across America. But on a remote family farm in the hills of Virginia, a storm of evil has been brewing for years. Now for a group of young people hitchhiking to a rally in D.C., a detour to the nightmare homestead of Staunton's will rip apart their young lives forever. A grisly secret is waiting. The raw terror is growing. And the clan's brutal harvest is about to begin.

While traveling through the desert for an appointment with a client, the businessman David Mann from California passes a slow and old tanker truck. The psychotic truck driver feels offended and chases David along the empty highway trying to kill him.